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Review
. 2015;4(6):411-29.
doi: 10.2217/cns.15.21. Epub 2015 Oct 26.

Pituitary adenomas: historical perspective, surgical management and future directions

Debebe Theodros  1 , Mira Patel  1 , Jacob Ruzevick  1 , Michael Lim  1 , Chetan Bettegowda  1
Affiliations
Review

Pituitary adenomas: historical perspective, surgical management and future directions

Debebe Theodros et al. CNS Oncol. 2015.

Abstract

Pituitary adenomas are among the most common central nervous system tumors. They represent a diverse group of neoplasms that may or may not secrete hormones based on their cell of origin. Epidemiologic studies have documented the incidence of pituitary adenomas within the general population to be as high as 16.7%. A growing body of work has helped to elucidate the pathogenesis of these tumors. Each subtype has been shown to demonstrate unique cellular changes potentially leading to tumorigenesis. Surgical advancements over several decades have included microsurgery and the employment of the endoscope for surgical resection. These advancements increase the likelihood of gross-total resection and have resulted in decreased patient morbidity.

Keywords: microsurgery; pituitary adenomas; transsphenoidal surgery.

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Conflict of interest statement

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

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