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Review
. 1989 Apr 7;244(4900):41-7.
doi: 10.1126/science.2649979.

The purine path to chemotherapy

G B Elion  1
Affiliations
Review

The purine path to chemotherapy

G B Elion. Science. .

Abstract

Research on antimetabolites of nucleic acid purines led to drugs for the treatment of acute leukemia (6-mercaptopurine and thioguanine), gout and hyperuricemia (allopurinol), and herpesvirus infections (acyclovir), and for the prevention of organ transplant rejection (azathioprine).

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