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Case Reports
. 2015 Sep 29;7(3):253-62.
doi: 10.1159/000439264. eCollection 2015 Sep-Dec.

Cutaneous Eruption due to Telaprevir

Eduardo Mastrangelo Marinho Falcão  1 , Beatriz Moritz Trope  1 , Mariana Marteleto Godinho  1 , Leonardo Hoehl Carneiro  2 , João Marcello de Araujo-Neto  3 , Cristiane Alves Villela Nogueira  3 , Marcia Ramos-E-Silva  1
Affiliations
Case Reports

Cutaneous Eruption due to Telaprevir

Eduardo Mastrangelo Marinho Falcão et al. Case Rep Dermatol. .

Abstract

Hepatitis C virus (HCV) chronically infects 0.5-3% of the world population. A large group of patients develop cirrhosis and its complications. Since 2011, telaprevir and boceprevir are used, improving the disease evolution. One of the main side effects of these drugs is skin eruption. We report a 53-year-old patient with cirrhosis due to HCV who started the classic treatment associated with telaprevir. In the ninth week, he presented a severe rash that required the interruption of this drug. We emphasize the importance of early recognition and appropriate management of adverse skin reaction.

Keywords: Drug eruption; Hepatitis C; Telaprevir.

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Figures

Fig. 1
Fig. 1
Skin lesions on the back.
Fig. 2
Fig. 2
Skin lesions on the chest.
Fig. 3
Fig. 3
Ulcers on the lower lip.
Fig. 4
Fig. 4
Skin lesions on the legs.
Fig. 5
Fig. 5
Perivascular lymphocytic infiltrate, intense extravasation of red blood cells and endothelial hyperplasia, compatible with drug eruption. HE. Original magnification. ×100.
Fig. 6
Fig. 6
Perivascular infiltrate at a higher magnification. HE. Original magnification. ×100.
Fig. 7
Fig. 7
Skin adverse reaction to telaprevir: classification and management. Adapted from Cacoub et al. [11].
See this image and copyright information in PMC

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