Primary Bladder Neurofibroma: A Rare Case with Clinical Implications and Diagnostic Challenges

Abstract

Neurofibroma of the genito-urinary tract is rare. Urinary bladder is the commonest organ involved in cases of urinary tract involvement. Patients present early in life and there is male preponderance. We discuss here a case of primary neurofibroma of the urinary bladder in a 52-year-male presenting with haematuria, irritative bladder symptoms and pelvic mass. Cystoscopy showed a swelling in the left lateral wall. A transurethral biopsy revealed neurofibroma of the urinary bladder. Immunohistochemical studies confirmed the diagnosis.

Keywords: Imaging studies; Immunostains; Urinary tract.

[Table/Fig-1]:

Cystoscopic findings show a swelling in the left lateral wall near the left ureteric orifice. The mucosa over the swelling was smooth and continuous

[Table/Fig-2a-d]:

(a) Circumscribed tumour and normal detrusor muscle (H & E stained; original magnification, X100). (b) Wavy nuclei (H & E stained; original magnification, X100). (c) Scattered bundles of collagen forming the tumour matrix (H & E stained; original magnification, X100). (d) The spindle cells are strongly immuno reactive for S-100 protein (S-100 immunohistochemistry; original magnification, X400)