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. 2015 Sep;9(9):TJ01-2.
doi: 10.7860/JCDR/2015/13840.6517. Epub 2015 Sep 1.

Lhermitte-Duclos Disease: Diagnosis on MRI, MR Spectroscopy, CT and Positron Emission Tomography

Neeraj Jain  1 , Udit Chauhan  1 , Vandana Goel  2 , Sunil Kumar Puri  3
Affiliations

Lhermitte-Duclos Disease: Diagnosis on MRI, MR Spectroscopy, CT and Positron Emission Tomography

Neeraj Jain et al. J Clin Diagn Res. 2015 Sep.
No abstract available

Keywords: Cerebellar mass; Hamartoma; Hypermetabolism.

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Figures

[Table/Fig-1]:
[Table/Fig-1]:
T2W axial (A) & FLAIR (B) coronal images reveals right cerebellar mass (arrows) with alternate bands of hyperintense and isointense signal giving “tiger stripes” appearance with mass effect over cisterna magna & 4th ventricle
[Table/Fig-2]:
[Table/Fig-2]:
T1W sagittal image reveals alternating bands of relative isointense and hypointense signal within the lesion (arrow) with mild inferior tonsillar herniation
[Table/Fig-3]:
[Table/Fig-3]:
MRS image reveals reduced peaks of NAA and choline, decreased Cho/Cr ratio (0.65). NAA/Cr (1.02) & NAA/Cho (0.94) ratios were also reduced compared to normal
[Table/Fig-4]:
[Table/Fig-4]:
PET reveals increased FDG uptake in the lesion suggesting hypermetabolism (arrow)
[Table/Fig-5]:
[Table/Fig-5]:
PET, CT reveals increased FDG uptake by the right cerebellar mass (arrow)
See this image and copyright information in PMC

References

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    1. Ambler M, Pogacar S, Sidman R. Lhermitte- Duclos disease (granular cell hypertrophy of the cerebellum): pathological analysis of the first familial cases. J Neuro-pathol Exp Neurol. 1969;28:622–47. - PubMed
    1. Williams III DW, Elster AD, Ginsberg LE, Stanton C. Recurrent Lhermitte- Duclos disease: report of two cases and association with Cowden’s disease. AJNR Am J Neuroradiol. 1992;13:287–90. - PMC - PubMed
    1. Awwad E, Levy E, Martin DS, et al. Atypical MR appearance of Lhermitte- Duclos disease with contrast enhancement. AJNR Am J Neuroradiol. 1995;16:1719–20. - PMC - PubMed

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