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. 2015 Sep;9(9):UC14-8.
doi: 10.7860/JCDR/2015/14964.6457. Epub 2015 Sep 1.

Evaluation of Efficacy of Epidural Clonidine with 0.5% Bupivacaine for Postoperative Analgesia for Orthopaedic Lower Limb Surgeries

Karthik Krishnamoorthy  1 , Saravanan Ravi  1 , Ilango Ganesan  1
Affiliations

Evaluation of Efficacy of Epidural Clonidine with 0.5% Bupivacaine for Postoperative Analgesia for Orthopaedic Lower Limb Surgeries

Karthik Krishnamoorthy et al. J Clin Diagn Res. 2015 Sep.

Abstract

Objective: The objective of this study is to evaluate the efficacy of epidural clonidine in intra and postoperative analgesia, the level of sedation caused by clonidine and monitor its side effects.

Materials and methods: Forty patients of ASA1 & ASA2 scheduled for lower limb orthopaediac surgeries were chosen for the study. Study group received 50μg of clonidine diluted to 1ml along with first dose of epidural injection and Control group received 1ml of normal saline along with first dose of epidural. Intra and postoperative vitals, verbal pain rating scale (VRS), sedation score and number of rescue anlgesics required postoperatively were noted. Patients received rescue analgesic when VRS was 1.

Results: Addition of clonidine to bupivacaine definitely improves the quality of analgesia by reducing the overall pain score, prolonging the duration of the time of first rescue analgesia and causing reduction of total analgesic consumption in the postoperative period without any hemodynamic instability. Sedation may be beneficial during the intraoperative period.

Conclusion: Epidural clonidine produces long lasting, good quality analgesia with good level of sedation and with minimal side effects.

Keywords: Epidural anaesthesia; Postoperative analgesia; Regional anaesthesia.

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References

    1. Rodgers A, Walker N, Schug S. Reduction of post operative mortality and morbidity with epidural or spinal anaesthesia: Results from overview of randomised trials. BMJ. 2000;321:1493–97. - PMC - PubMed
    1. Vekatraman R, Sandhiya R. Evaluation of Efficacy of Epidural Butorphanol Tartarate for Postoperative Analgesia. International J of Pharmacy and Pharmaceutical Sciences. 2015;7(2):52–54.
    1. Asano T, Dohi S, Ohta S, Shimonaka H, Iida H. Antinociception by epidural and systemic alpha (2)-adrenoceptor agonists and their binding affinity in rat spinal cord and brain. Anesth Analg. 2000;90:400–07. - PubMed
    1. Armand S, Langlade A, Boutros A, Lobjoit K, Monrigal C, Ramboatiana R, et al. Meta-analysis of the efficacy of extradural clonidine to relieve postoperative pain: An impossible task. Br J Anaesth. 1998;81:126–34. - PubMed
    1. Vieira AM, Schnaider TB, Costa FA, et al. Analgesia and sedation with epidural clonidine associated to 0.75% ropivacaine in the postoperative period of open cholecystectomy. Rev Bras Anestesiol. [online] 2003;53(5):586–90. - PubMed

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