Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Dec;5(1):31.
doi: 10.1186/s12348-015-0061-0. Epub 2015 Oct 26.

Acute onset anterior uveitis after darbepoetin alfa infusion

Jonathan Li  1 , Stephen E Orlin  2 , Karen E Revere  3 , John H Kempen  4   5   6
Affiliations

Acute onset anterior uveitis after darbepoetin alfa infusion

Jonathan Li et al. J Ophthalmic Inflamm Infect. 2015 Dec.

Abstract

A 79-year-old female with a 2-month history of newly diagnosed myelodysplastic syndrome for which she received blood transfusion with darbepoetin alfa presented with bilateral anterior uveitis 1 day after her fourth transfusion. On exam, visual acuity was 20/20 in both eyes with biomicroscopy notable for conjunctival injection and anterior chamber cell and flare consistent with anterior uveitis. She had no systemic symptoms, no history of eye trauma, and no known infections. This case, along with prior reports in the literature, suggests that anterior uveitis may be an idiosyncratic complication of darbepoetin alfa therapy.

Keywords: Anterior uveitis; Darbepoetin; Erythropoietin; Iritis.

PubMed Disclaimer

References

    1. Fraunfelder FW, Rosenbaum JT. Drug-induced uveitis: incidence, prevention and treatment. Drug Saf. 1997;17(3):197–207. doi: 10.2165/00002018-199717030-00005. - DOI - PubMed
    1. Beiran I, Krasnitz I, Mezer E, Meyer E, Miller B. Erythropoietin-induced iritis-like reaction. Eur J Ophthalmol. 1996;6(1):14–6. - PubMed
    1. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, Janecek E, Domecq C, Greenblatt DJ. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30(2):239–45. doi: 10.1038/clpt.1981.154. - DOI - PubMed
    1. Moorthy RS, London NJ, Garg SJ, Cunningham ET., Jr Drug-induced uveitis. Curr Opin Ophthalmol. 2013;24(6):589–97. doi: 10.1097/01.icu.0000434534.32063.5c. - DOI - PubMed
    1. Fietta P, Manganelli P, Lodigiani L. Clodronate induced uveitis. Ann Rheum Dis. 2003;62:378. doi: 10.1136/ard.62.4.378. - DOI - PMC - PubMed