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. 2015 Oct 26;60(1):624-7.
doi: 10.1128/AAC.01346-15. Print 2016 Jan.

Emergence of Mutations in the K13 Propeller Gene of Plasmodium falciparum Isolates from Dakar, Senegal, in 2013-2014

Agathe Boussaroque  1 , Bécaye Fall  2 , Marylin Madamet  3 , Cheikhou Camara  4 , Nicolas Benoit  3 , Mansour Fall  5 , Aminata Nakoulima  6 , Pierre Dionne  7 , Kadidiatou Ba Fall  8 , Bakary Diatta  5 , Yaya Diémé  2 , Boubacar Wade  9 , Bruno Pradines  10
Affiliations

Emergence of Mutations in the K13 Propeller Gene of Plasmodium falciparum Isolates from Dakar, Senegal, in 2013-2014

Agathe Boussaroque et al. Antimicrob Agents Chemother. .

Abstract

The kelch 13 (K13) propeller gene is associated with artemisinin resistance. In a previous work, there were no mutations found in 138 Plasmodium falciparum isolates collected in 2012 and 2013 from patients residing in Dakar, Senegal (M. Torrentino-Madamet et al., Malar J 13:472, 2014, http://dx.doi.org/10.1186/1475-2875-13-472). However, the N554H, Q613H, and V637I mutations were identified in the propeller region of K13 in 92 (5.5%) isolates in 2013 and 2014. There were five polymorphisms identified in the Plasmodium/Apicomplexa-specific domain (K123R, N137S, N142NN/NNN, T149S, and K189T/N).

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Figures

FIG 1
FIG 1
Locations of the mutations in the predicted three-dimensional (3D) model of the K13 propeller domain (RasTop software, Phyre 2 server). The locations of the various mutations are indicated by spheres, in which yellow represents mutations correlated with artemisinin resistance reported by Ariey et al. (4) and pink represents mutations observed in Dakar, Senegal.
See this image and copyright information in PMC

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