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Review
. 2015 Nov;20(11):1365-71.
doi: 10.1016/j.drudis.2015.09.015. Epub 2015 Oct 23.

Lost in space: design of experiments and scientific exploration in a Hogarth Universe

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Review

Lost in space: design of experiments and scientific exploration in a Hogarth Universe

Dennis W Lendrem et al. Drug Discov Today. 2015 Nov.

Abstract

A Hogarth, or 'wicked', universe is an irregular environment generating data to support erroneous beliefs. Here, we argue that development scientists often work in such a universe. We demonstrate that exploring these multidimensional spaces using small experiments guided by scientific intuition alone, gives rise to an illusion of validity and a misplaced confidence in that scientific intuition. By contrast, design of experiments (DOE) permits the efficient mapping of such complex, multidimensional spaces. We describe simulation tools that enable research scientists to explore these spaces in relative safety.

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