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Editorial
. 2015;11(10):1709-10.
doi: 10.1080/15548627.2015.1084461.

The amino acid transporter SLC38A9 regulates MTORC1 and autophagy

Meiyan Jin  1 , Daniel J Klionsky  1
Affiliations
Editorial

The amino acid transporter SLC38A9 regulates MTORC1 and autophagy

Meiyan Jin et al. Autophagy. 2015.

Abstract

The mechanistic target of rapamycin (serine/threonine kinase) complex 1 (MTORC1) is a master regulator of macroautophagy (hereafter autophagy) that responds to different environmental nutrients, including amino acids, glucose, and growth factors. The identity of the amino acid-sensing component of the MTORC1 machinery had remained elusive until a lysosomal low-affinity amino acid transporter, SLC38A9 (solute carrier family 38, member 9), was recently characterized as a novel component of the Ragulator-RRAG GTPase complex by 3 independent research groups.

Keywords: RRAG GTPase; TOR; autophagy; lysosome; stress.

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References

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