Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2015;14(21):3347-8.
doi: 10.1080/15384101.2015.1093445.

Tumor heterogeneity-induced signaling regulates SCLC metastasis

Min-chul Kwon  1 , Anton Berns  1   2
Affiliations
Editorial

Tumor heterogeneity-induced signaling regulates SCLC metastasis

Min-chul Kwon et al. Cell Cycle. 2015.
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Intravenous injection of neuroendocrine (NE) cell alone generates liver metastasis, while co-injection of NE and mesenchymal-like (NonNE) tumor cells into the bloodstream also causes frequent mediastinal metastasis and occasional lung metastasis. NonNE tumor cells in subcutaneously transplanted mice are crucial for the invasion capacity of NE tumor cells (Top). Fgf2 secreted by NonNE cells induces Pea3 expression via MAPK activation in NE cells. Pea3 induction is required for the metastasis of NE cells. NonNE cells also secrete extracellular matrix (ECM) remodeling factors such as LOX, Cathepsin, and PAI-1. These ECM modifiers likely further facilitate metastasis of SCLC (Bottom).
See this image and copyright information in PMC

Comment on

References

    1. Junttila MR, de Sauvage FJ. Nature 2013; 501:346-54; PMID:24048067; http://dx.doi.org/10.1038/nature12626 - DOI - PubMed
    1. Calbo J, et al. Cancer Cell 2011; 19:244-56; PMID:21316603; http://dx.doi.org/10.1016/j.ccr.2010.12.021 - DOI - PubMed
    1. Cleary AS, et al. Nature 2014; 508:113-7; PMID:24695311; http://dx.doi.org/10.1038/nature13187 - DOI - PMC - PubMed
    1. Kwon MC, et al. Genes Dev 2015; 29:1587-92; PMID:26215568; http://dx.doi.org/10.1101/gad.262998.115 - DOI - PMC - PubMed
    1. Oh S, et al. Biochimica Et biophysica Acta 2012; 1826:1-12; PMID:22425584 - PMC - PubMed

MeSH terms

Substances

LinkOut - more resources