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Review
. 2015 Dec;16(12):753-61.
doi: 10.1038/nrm4080. Epub 2015 Oct 28.

The systematic analysis of protein-lipid interactions comes of age

Antoine-Emmanuel Saliba  1 , Ivana Vonkova  2 , Anne-Claude Gavin  3
Affiliations
Review

The systematic analysis of protein-lipid interactions comes of age

Antoine-Emmanuel Saliba et al. Nat Rev Mol Cell Biol. 2015 Dec.

Abstract

Lipids tailor membrane identities and function as molecular hubs in all cellular processes. However, the ways in which lipids modulate protein function and structure are poorly understood and still require systematic investigation. In this Innovation article, we summarize pioneering technologies, including lipid-overlay assays, lipid pull-down assays, affinity-purification lipidomics and the liposome microarray-based assay (LiMA), that will enable protein-lipid interactions to be deciphered on a systems level. We discuss how these technologies can be applied to the charting of system-wide networks and to the development of new pharmaceutical strategies.

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