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. 2016 Feb;142(2):505-20.
doi: 10.1007/s00432-015-2058-3. Epub 2015 Oct 27.

Outcome and fewer indications for adjuvant therapy for patients with oral squamous cell carcinomas under standardized tumor board conditions

Alexander Gröbe  1 , Lena Rybak  2 , Gerhard Schön  3 , Ralf Smeets  2 , Silke Tribius  4 , Philippe Schafhausen  5 , Till S Clauditz  6 , Henning Hanken  2 , Max Heiland  2
Affiliations

Outcome and fewer indications for adjuvant therapy for patients with oral squamous cell carcinomas under standardized tumor board conditions

Alexander Gröbe et al. J Cancer Res Clin Oncol. 2016 Feb.

Abstract

Purpose: The aim of our study was to review the outcome of patients with oral squamous cell carcinoma (OSCC) treated according to the current diagnostic and treatment protocols ["Tumor Board Group" (TBG)] compared to patients diagnosed before the introduction of standardized and certified guidelines ["Conventional Group" (CG)]. We also analyzed the influence of prognostic factors on overall survival (OS), disease-free survival (DFS) and recurrence-free survival (RFS) rates.

Methods: A total of 321 patients (TBG 95 patients and CG 226 patients) with histologically confirmed OSCC were included in our study. RFS, DFS and OS rates were analyzed by Kaplan-Meier estimates. Cox regression was performed for multivariate analysis of prognostic factors. Results were statistically significant with a p value of <0.05.

Results: T, N, AJCC stage, age and therapy resulted to be independent risk factors for OS and DFS. We were not able to identify statistically significant prognostic factors for RFS apart from grading. 31.58% of patients from the TBG received postoperative adjuvant treatment compared to 74.78% within the CG. The OS rate was 79.63% at 30 months for patients from the TBG in comparison with 65.54% for patients from the CG.

Conclusion: The implementation of standardized guidelines including the establishment of the "Tumor Board Conference" results in a higher percentage of patients receiving surgery as only treatment and in better OS rates. To further support this positive trend, patients shall be followed longer and analyzed in future. T, N and M as well as AJCC stage were identified as most important prognostic factors for OS and DFS in our study.

Keywords: Adjuvant therapy; Oral squamous cell carcinoma (OSCC); Outcome; Prognosis.

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Conflict of interest statement

All authors of this manuscript declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Overall survival according to stage. We grouped patients with early stages (I, II) together and compared their overall survival rates to those who had advanced stages (III, IV). Patients with early staged tumors had significantly better survival rates compared to patients with advanced tumors
Fig. 2
Fig. 2
Disease-free survival according to stage. We grouped patients with early stages (I, II) together and compared their disease-free survival rates to those who had advanced stages (III, IV). Patients with early staged tumors had significantly better survival rates compared to patients with advanced tumors
Fig. 3
Fig. 3
Overall survival TBG compared to CG. We compared overall survival rates of patients from the TBG to those of patients from the CG. Overall survival rates were better for patients from the TBG
Fig. 4
Fig. 4
Overall survival TBG compared to CG according to stage. We compared overall survival rates of patients from the TBG to those of patients from the CG according to stage. We grouped stage into early (I, II) and advanced stages (III, IV). Overall survival rates were better for patients from the TBG with early and advanced tumors
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References

    1. Ang KK et al (2010) Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 363:24–35. doi:10.1056/NEJMoa0912217 - PMC - PubMed
    1. Arbyn M et al (2007) IARC monographs on the evaluation of carcinogenic risks to humans, vol 90. International Agency for Research on Cancer, Lyon - PMC - PubMed
    1. Arduino PG et al (2008) Clinical and histopathologic independent prognostic factors in oral squamous cell carcinoma: a retrospective study of 334 cases. J Oral Maxillofac Surg 66:1570–1579. doi:10.1016/j.joms.2007.12.024 - PubMed
    1. Ash CS, Nason RW, Abdoh AA, Cohen MA (2000) Prognostic implications of mandibular invasion in oral cancer. Head Neck 22:794–798 - PubMed
    1. Baghi M, Hambek M, May A, Radeloff A, Gstoettner W, Knecht R (2006) Adjuvant docetaxel, cisplatin and 5-fluorouracil (TPF) in locally advanced squamous cell carcinoma of the head and neck. Anticancer Res 26:559–563 - PubMed

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