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. 2016 Apr;37(4):4597-602.
doi: 10.1007/s13277-015-4282-5. Epub 2015 Oct 27.

SATB2 suppresses gastric cancer cell proliferation and migration

Liucheng Wu  1 , Jiansi Chen  2 , Yuzhou Qin  2 , Xianwei Mo  2 , Minwei Huang  2 , Haiming Ru  2 , Yang Yang  2 , Jungang Liu  2 , Yuan Lin  2
Affiliations
Free article

SATB2 suppresses gastric cancer cell proliferation and migration

Liucheng Wu et al. Tumour Biol. 2016 Apr.
Free article

Abstract

Gastric cancer is one of the death-related malignant tumors worldwide. It remains a challenge for the diagnosis and treatment of gastric cancer. Special AT-rich sequence-binding protein 2 (SATB2) is a new tumor suppressive gene and plays important roles in many cancers. However, the role of SATB2 in gastric cancer is still unknown. In the present study, we demonstrated that downregulation of SATB2 was associated with shortened survival in patients with gastric cancer. Ectopic expression of SATB2 inhibited gastric cancer cell proliferation, colony formation, and migration. Overexpression of SATB2 repressed the expression of extracellular signal-regulated kinase 5 (ERK5), and activation of ERK5 restored the SATB2-induced inhibition of proliferation and migration in gastric cancer. This study provided evidence that SATB2 acted as a tumor suppressive gene gastric cancer, serving as a potential therapeutic target.

Keywords: ERK5; Gastric cancer; Proliferation; SATB2.

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