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. 2015 Oct;12(4):443-50.
doi: 10.4306/pi.2015.12.4.443. Epub 2015 Sep 30.

Associations of Pulmonary Function with Dementia and Depression in an Older Korean Population

Suelin Yoon  1 , Jae-Min Kim  1 , Hee-Ju Kang  1 , Kyung-Yeol Bae  1 , Sung-Wan Kim  1 , Il-Seon Shin  1 , Jin-Sang Yoon  1
Affiliations

Associations of Pulmonary Function with Dementia and Depression in an Older Korean Population

Suelin Yoon et al. Psychiatry Investig. 2015 Oct.

Abstract

Objective: Previous studies reported an association between pulmonary function and cognitive function. However, not much has been investigated in this regard concerning dementia in a community population, taking depression into account. We aimed to examine the associations of pulmonary function with dementia and depression in a community-dwelling elderly population.

Methods: A total of 1,038 participants were evaluated for dementia and depression using the Korean version of the Geriatric Mental State Schedule B3 (GMS B3-K), the Community Screening Interview for Dementia-Korean version (CSID-K) and a modified 10-item Word List Learning from the Consortium to Establish a Registry of Alzheimer's Disease (CERAD). Pulmonary function was measured as forced expiratory volume in 1 s (FEV1) from a forced expiratory maneuver.

Results: Prevalence rates of dementia and depression were 11.0% and 10.4%, respectively. Individuals who were diagnosed with dementia manifested a lower mean FEV1, as compared to those without dementia after adjusting for potential confounders, including disability and depression [OR=1.34 (1.05-1.72)]. Following gender-stratified analysis, the association was only statistically significant in women [OR=1.40 (1.04-1.89)]. The association between depression and mean FEV1 was less significant compared to dementia [OR=1.32 (1.10-1.58)]. However, the association was no longer significant after adjusting for age and years of education. No association was significant in the gender-stratified analysis.

Conclusion: Decreased pulmonary function was associated with dementia status only in an older female Korean population. Pulmonary function and depression were not significantly associated in either gender.

Keywords: Dementia; Depression; Disability; Forced expiratory volume; Pulmonary function.

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Figures

Figure 1
Figure 1. Prevalence rates of dementia and depression by forced expiratory volume in one second (FEV1) quartiles.
See this image and copyright information in PMC

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