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Case Reports
. 2015 Oct;3(10):790-2.
doi: 10.1002/ccr3.342. Epub 2015 Aug 26.

Anticoagulant therapy with rivaroxaban in a young patient with paroxysmal nocturnal hemoglobinuria

Affiliations
Case Reports

Anticoagulant therapy with rivaroxaban in a young patient with paroxysmal nocturnal hemoglobinuria

Francesco Dragoni et al. Clin Case Rep. 2015 Oct.

Abstract

The new direct oral anticoagulants such us rivaroxaban, could play an important role in the anticoagulant treatment of patients with paroxysmal nocturnal hemoglobinuria where anticoagulant treatment is complex to run, since they have shown a reduction in serious bleeding complications compared to antithrombotic therapy with classical vitamin k antagonist.

Keywords: Anticoagulant therapy; bleeding complication; paroxysmal nocturnal hemoglobinuria; rivaroxaban; thrombosis.

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References

    1. Rosti V. The molecular basis of paroxysmal nocturnal hemoglobinuria. Haematologica. 2000;85:82–87. - PubMed
    1. Socie G, Gramont A, Rio B, Leporrier M, Rose C, Heudier P, et al. Paroxysmal nocturnal haemoglobinuria: long term follow-up and prognostic factors. Lancet. 1996;348:573–577. - PubMed
    1. Hillmen P, Muus P, Duhrsen U, Risitano AM, Schulbert J, Luzzatto L, et al. Effect of the complement inhibitor eculizumab on thromboembolism in patients with paroxysmal nocturnal hemoglobinuria. Blood. 2007;110:4123–4128. - PubMed
    1. Eriksson BI, Borris LC, Friedman RJ, Haas S, Huisman MV, Kakkar AK, et al. for the RECORD1 Study Group. Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty. N. Engl. J. Med. 2008;358:2765–2775. - PubMed
    1. Prins MH, Lensing AWA, Bauersachs R, van Bellen B, Bounameaux H, Brighton TA, et al. and on behalf of the EINSTEIN Investigators. Oral rivaroxaban versus standard therapy for the treatment of symptomatic venous thromboembolism: a pooled analysis of the EINSTEIN-DVT and PE randomized studies. Thromb. J. 2008;20:11–21. - PMC - PubMed

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