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Case Reports
. 2015 Oct;3(10):862-5.
doi: 10.1002/ccr3.358. Epub 2015 Sep 7.

Successful treatment of fetal hemolytic disease due to glucose phosphate isomerase deficiency (GPI) using repeated intrauterine transfusions: a case report

Phebe N Adama van Scheltema  1 , Ai Zhang  1 , Lynne M Ball  2 , Sylke J Steggerda  3 , Richard van Wijk  4 , Dietje E Fransen van de Putte  5 , Inge L van Kamp  1
Affiliations
Case Reports

Successful treatment of fetal hemolytic disease due to glucose phosphate isomerase deficiency (GPI) using repeated intrauterine transfusions: a case report

Phebe N Adama van Scheltema et al. Clin Case Rep. 2015 Oct.

Abstract

Hemolytic anemia due to GPI deficiency can be severe and life threatening during fetal life. When parents decline invasive testing, ultrasound monitoring of fetuses at risk is feasible. Intrauterine transfusion can be effective for the treatment of severe fetal anemia due to GPI deficiency.

Keywords: Fetal anemia; GPI deficiency; intrauterine transfusion.

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Figures

Figure 1
Figure 1
Peak systolic velocities (Vmax) in the middle cerebral artery of the fetus. The lowest line represents 1.0 MoM. The highest line represents 1.5 MoM. There is suspicion of fetal anemia when Vmax in the middle cerebral artery exceeds 1.5 MoM.
See this image and copyright information in PMC

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