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. 2015 Oct;20(10):106012.
doi: 10.1117/1.JBO.20.10.106012.

Monitoring photodynamic therapy with photoacoustic microscopy

Peng Shao  1 , David W Chapman  2 , Ronald B Moore  2 , Roger J Zemp  1
Affiliations
Free article

Monitoring photodynamic therapy with photoacoustic microscopy

Peng Shao et al. J Biomed Opt. 2015 Oct.
Free article

Abstract

Abstract. We present our work on examining the feasibility of monitoring photodynamic therapy (PDT)-induced vasculature change with acoustic-resolution photoacoustic microscopy (PAM). Verteporfin, an FDA-approved photosensitizer for clinical PDT, was utilized. With a 60-μm-resolution PAM system, we demonstrated the capability of PAM to monitor PDT-induced vasculature variations in a chick chorioallantoic membrane model with topical application and in a rat ear with intravenous injection of the photosensitizer. We also showed oxygen saturation change in target blood vessels due to PDT. Success of the present approach may potentially lead to the application of PAM imaging in evaluating PDT efficacy, guiding treatment, and predicting responders from nonresponders.

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References

    1. Clin Cancer Res. 2007 Dec 15;13(24):7496-505 - PubMed
    1. Chem Rev. 2010 May 12;110(5):2795-838 - PubMed
    1. Gastrointest Endosc. 2007 Aug;66(2):326-33 - PubMed
    1. J Biomed Opt. 2007 May-Jun;12(3):034022 - PubMed
    1. J Biomed Opt. 2007 Jan-Feb;12(1):014001 - PubMed

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