The Regulatory T Cell: Jack-Of-All-Trades

Ajithkumar Vasanthakumar¹, Axel Kallies²

Affiliations

¹ The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3052, Australia; The Department of Medical Biology, University of Melbourne, Parkville, Victoria, 3010, Australia.
² The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3052, Australia; The Department of Medical Biology, University of Melbourne, Parkville, Victoria, 3010, Australia. Electronic address: kallies@wehi.edu.au.

PMID: 26511762
DOI: 10.1016/j.it.2015.10.002

Comment

The Regulatory T Cell: Jack-Of-All-Trades

Ajithkumar Vasanthakumar et al. Trends Immunol. 2015 Dec.

. 2015 Dec;36(12):756-758.

doi: 10.1016/j.it.2015.10.002. Epub 2015 Oct 25.

Authors

Ajithkumar Vasanthakumar¹, Axel Kallies²

Affiliations

¹ The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3052, Australia; The Department of Medical Biology, University of Melbourne, Parkville, Victoria, 3010, Australia.
² The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3052, Australia; The Department of Medical Biology, University of Melbourne, Parkville, Victoria, 3010, Australia. Electronic address: kallies@wehi.edu.au.

PMID: 26511762
DOI: 10.1016/j.it.2015.10.002

Abstract

Foxp3(+) regulatory T (Treg) cells suppress auto-reactive and inflammatory T cells to maintain immune homeostasis. In a recent study, Rudensky and colleagues demonstrate the ability of Treg cells to facilitate tissue repair, a non-canonical Treg cell function accomplished by amphiregulin and mediated by cytokines interleukin (IL)-18 and IL-33.

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A Distinct Function of Regulatory T Cells in Tissue Protection.
Arpaia N, Green JA, Moltedo B, Arvey A, Hemmers S, Yuan S, Treuting PM, Rudensky AY. Arpaia N, et al. Cell. 2015 Aug 27;162(5):1078-89. doi: 10.1016/j.cell.2015.08.021. Cell. 2015. PMID: 26317471 Free PMC article.

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The Regulatory T Cell: Jack-Of-All-Trades

Affiliations

The Regulatory T Cell: Jack-Of-All-Trades

Authors

Affiliations

Abstract

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Medical

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