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About 200 journal articles reported research on Tourette syndrome and other tic disorders in 2014. Here we briefly summarize a few of the reports that seemed most important or interesting, ranging from animal models to human studies. Readers can comment on our choices or provide their own favorites using the tools on the online article.
Competing interests: Dr. Black participates in a clinical trial supported by Psyadon Pharmaceuticals. Dr. Black is an (unpaid) member of the F1000Research Advisory Board.
Figures
Figure 1.. Publications on Tourette syndrome.
The…
Figure 1.. Publications on Tourette syndrome.
The number of new publications on Tourette syndrome or…
Figure 1.. Publications on Tourette syndrome.
The number of new publications on Tourette syndrome or other tic disorders each year was estimated from PubMed. The colored line represents locally weighted scatterplot smoothing (LOWESS) of the primary data. PubMed was searched using the search string “(“Tic Disorders”[MeSH] OR Tourette NOT Tourette[AU]) AND
year[PDAT] NOT
year+1[PDAT]” for each year from 1950 through 2014. (This strategy assigns articles to the year in which the final publication appeared, to prevent double-counting “early online” and final publication dates for about 250 publications since 2005). The graph was generated by matplotlib in python (see
Supplementary material).
Castellan Baldan L, Williams KA, Gallezot JD, et al. : Histidine decarboxylase deficiency causes Tourette syndrome: parallel findings in humans and mice. Neuron. 2014;81(1):77–90. 10.1016/j.neuron.2013.10.052
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Castellan Baldan L, Williams KA, Gallezot JD, et al. : Erratum. Histidine decarboxylase deficiency causes Tourette syndrome: parallel findings in humans and mice. Neuron. 2014;82(5):1186–1187. 10.1016/j.neuron.2014.05.023
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Ercan-Sencicek AG, Stillman AA, Ghosh AK, et al. : L-histidine decarboxylase and Tourette’s syndrome. N Engl J Med. 2010;362(20):1901–1908. 10.1056/NEJMoa0907006
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Karagiannidis I, Dehning S, Sandor P, et al. : Support of the histaminergic hypothesis in Tourette syndrome: association of the histamine decarboxylase gene in a large sample of families. J Med Genet. 2013;50(11):760–764. 10.1136/jmedgenet-2013-101637
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Parmentier R, Ohtsu H, Djebbara-Hannas Z, et al. : Anatomical, physiological, and pharmacological characteristics of histidine decarboxylase knock-out mice: evidence for the role of brain histamine in behavioral and sleep-wake control. J Neurosci. 2002;22(17):7695–7711.
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