TRIM-NHL proteins in development and disease

Abstract

TRIM-NHL proteins are key regulators of developmental transitions, for example promoting differentiation, while inhibiting cell growth and proliferation, in stem and progenitor cells. Abnormalities in these proteins have been also associated with human diseases, particularly affecting muscular and neuronal functions, making them potential targets for therapeutic intervention. The purpose of this review is to provide a systematic and comprehensive summary on the most studied TRIM-NHL proteins, highlighting examples where connections were established between structural features, molecular functions and biological outcomes.

Keywords: Bardet-Biedl syndrome; Brat; LIN-41; Limb girdle muscular dystrophy 2H; Mei-P26; NHL; Sarcotubular myopathy; TRIM; TRIM32; TRIM71.