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Comment
. 2015 Nov;17(11):1373-5.
doi: 10.1038/ncb3261.

Endosomal integrin signals for survival

Elena Rainero  1 , Jim C Norman  1
Affiliations
Free article
Comment

Endosomal integrin signals for survival

Elena Rainero et al. Nat Cell Biol. 2015 Nov.
Free article

Abstract

The mechanisms underlying integrin-dependent signalling are a topic of continued study. Endocytosed integrins are now shown to drive assembly of signalling complexes on the cytoplasmic face of endocytic membranes to promote cancer cell survival and increase metastatic capacity following cell detachment.

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Comment on

  • Integrin endosomal signalling suppresses anoikis.
    Alanko J, Mai A, Jacquemet G, Schauer K, Kaukonen R, Saari M, Goud B, Ivaska J. Alanko J, et al. Nat Cell Biol. 2015 Nov;17(11):1412-21. doi: 10.1038/ncb3250. Epub 2015 Oct 5. Nat Cell Biol. 2015. PMID: 26436690 Free PMC article.

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