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Comment
. 2015 Dec;31(12):610-612.
doi: 10.1016/j.pt.2015.10.005. Epub 2015 Oct 26.

A Bradyzoite is a Bradyzoite is a Bradyzoite?

Kami Kim  1
Affiliations
Comment

A Bradyzoite is a Bradyzoite is a Bradyzoite?

Kami Kim. Trends Parasitol. 2015 Dec.

Abstract

Bradyzoite forms of Toxoplasma gondii persist in tissue cysts for the lifetime of an infected host and can reactivate to cause clinical disease. It was thought that in vivo bradyzoites within tissue cysts are biologically inactive dormant forms that rarely replicate. Apparently, consensus was wrong.

Keywords: Toxoplasma; bradyzoite; tissue cyst.

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Figures

Figure 1
Figure 1. Toxoplasma tissue cysts harvested from mouse brains
The PruΔku80Δhxgprt strain stably expresses GFP-positive cysts during chronic infection. The images show examples of cysts observed at 5 weeks after intraperitoneal infection of C57BL/6 mice with tachyzoites of strain PruΔku80ΔhxgprtLDH2-GFP. Left images show bright-field laser confocal microscopy and right images are GFP fluorescence driven by the bradyzoite-specific LDH2 promoter. Images courtesy of Tadakimi Tomita and Louis Weiss.
See this image and copyright information in PMC

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References

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