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Review
. 2015 Nov;33(4):727-34.
doi: 10.1016/j.ncl.2015.07.013.

Amyotrophic Lateral Sclerosis: A Historical Perspective

Jonathan S Katz  1 , Mazen M Dimachkie  2 , Richard J Barohn  3
Affiliations
Review

Amyotrophic Lateral Sclerosis: A Historical Perspective

Jonathan S Katz et al. Neurol Clin. 2015 Nov.

Abstract

This article looks back in time to see where the foundational basis for the understanding of amyotrophic lateral sclerosis originated. This foundation was created primarily in France by Jean-Martin Charcot and his fellow countrymen and disciples, along with key contributions from early clinicians in England and Germany. The early work on amyotrophic lateral sclerosis provides a useful foundation for today's clinicians with respect to tying together genetic and biologic aspects of the disorder that have been discovered over the past few decades.

Keywords: Amyotrophic lateral sclerosis; Genotype; Jean-Martin Charcot; Phenotype.

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