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Editorial
. 2015;14(20):3209-10.
doi: 10.1080/15384101.2015.1084206.

Appetite for ER/nucleus destruction

Keisuke Mochida  1 , Hitoshi Nakatogawa  1   2
Affiliations
Editorial

Appetite for ER/nucleus destruction

Keisuke Mochida et al. Cell Cycle. 2015.
No abstract available

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Figures

Figure 1.
Figure 1.
Atg39 and Atg40 are autophagy receptors for the perinuclear ER/nucleus and the cytoplasmic/cortical ER, respectively. Atg39 localizes to the perinuclear ER membrane/nuclear envelope, and causes the autophagosomal sequestration of double-membraned vesicles, which are generated from these membranes and contain intranuclear components. Atg40 primarily localizes to the cytoplasmic/cortical ER, and loads part of these ER subdomains as folded tubules/sheets into autophagosomes. In these processes, Atg39 and Atg40 bind to Atg8 on growing autophagosomal membranes to facilitate the sequestration of the corresponding ER/nucleus fragments. Autophagosomes fuse with the vacuole, and vacuolar hydrolases degrade the sequestered fragments.
See this image and copyright information in PMC

Comment on

  • Regulation of endoplasmic reticulum turnover by selective autophagy.
    Khaminets A, Heinrich T, Mari M, Grumati P, Huebner AK, Akutsu M, Liebmann L, Stolz A, Nietzsche S, Koch N, Mauthe M, Katona I, Qualmann B, Weis J, Reggiori F, Kurth I, Hübner CA, Dikic I. Khaminets A, et al. Nature. 2015 Jun 18;522(7556):354-8. doi: 10.1038/nature14498. Epub 2015 Jun 3. Nature. 2015. PMID: 26040720

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