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. 2015:464:322-4.
doi: 10.1134/S1607672915050142. Epub 2015 Oct 31.

Novel bivalent positive allosteric modulators of AMPA receptor

M I Lavrov  1   2 , V V Grigor'ev  2 , S O Bachurin  2 , V A Palyulin  3   4 , N S Zefirov  1   2
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Novel bivalent positive allosteric modulators of AMPA receptor

M I Lavrov et al. Dokl Biochem Biophys. 2015.

Abstract

A positive allosteric modulator of AMPA receptors has been designed using computer-aided molecular modeling techniques. It possessed a record high experimentally confirmed potency in the picomolar concentration range and belongs to a new type of bivalent AMPA receptor ligands containing bicyclo[3.3.1]nonane scaffold. The suggested structure could serve as a basis for further optimization and development of drugs for the treatment of neurodegenerative diseases, cognition enhancement, and improvement of memory.

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