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. 2016 Feb;12(2):170-183.
doi: 10.1016/j.jalz.2015.08.165. Epub 2015 Oct 28.

Risk of dementia and death in the long-term follow-up of the Pittsburgh Cardiovascular Health Study-Cognition Study

Lewis H Kuller  1 , Oscar L Lopez  2 , James T Becker  3 , Yuefang Chang  4 , Anne B Newman  5
Affiliations

Risk of dementia and death in the long-term follow-up of the Pittsburgh Cardiovascular Health Study-Cognition Study

Lewis H Kuller et al. Alzheimers Dement. 2016 Feb.

Abstract

Introduction: Increasing life expectancy has resulted in a larger population of older individuals at risk of dementia.

Methods: The Cardiovascular Health Study-Cognition Study followed 532 participants from 1998-99 (mean age 79) to 2013 (mean age 93) for death and dementia.

Results: Risk of death was determined by extent of coronary artery calcium, high-sensitivity cardiac troponin, brain natriuretic peptide, and white matter grade. Significant predictors of dementia were age, apolipoprotein-E4, vocabulary raw score, hippocampal volume, ventricular size, cognitive performance, and number of blocks walked. By 2013, 160 of 532 were alive, including 19 cognitively normal. Those with normal cognition had higher grade education, better cognition test scores, greater hippocampal volume, faster gait speed, and number of blocks walked as compared with survivors who were demented.

Discussion: Few survived free of dementia and disability. Prevention and delay of cognitive decline for this older population is an imperative.

Keywords: Aging; Cognition; Dementia; Epidemiology; MRI.

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Figures

Figure 1
Figure 1
Selection of Participants of the CHS-CS
Figure 2
Figure 2
Procedures Over Time for the CHS-CS
Figure 3
Figure 3
Kaplan-Meier Cumulative Survival Curve Free of Dementia by Age and Time from 1998–99
Figure 4
Figure 4
Kaplan-Meier Cumulative Survival Curve Free of Dementia by ApoE4 Status, 1992–2013
Figure 5
Figure 5
Incidence of Dementia 1998–99 to 2012 by Hippocampal Volume Measured in 1998–99
See this image and copyright information in PMC

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