Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2015 Nov;100(11):1373-5.
doi: 10.3324/haematol.2015.136077.

The origin of relapse in pediatric T-cell acute lymphoblastic leukemia

Affiliations
Editorial

The origin of relapse in pediatric T-cell acute lymphoblastic leukemia

Carmen Vicente et al. Haematologica. 2015 Nov.
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Schematic representation of clonal evolution during the development of T-ALL by the stepwise accumulation of additional mutations. As described by Kunz et al. in this issue, relapse clones can originate from pre-leukemic clones by the acquisition of new mutations or can originate from the major diagnostic clone by the acquisition of additional mutations.

Comment on

References

    1. Nigro Lo L. Biology of childhood acute lymphoblastic leukemia. J Pediatr Hematol Oncol 2013;35(4):245–252. - PubMed
    1. Einsiedel HG, Stackelberg von A, Hartmann R, et al. Long-term outcome in children with relapsed ALL by risk-stratified salvage therapy: results of trial acute lymphoblastic leukemia-relapse study of the Berlin-Frankfurt-Münster Group 87. J Clin Oncol 2005;23(31):7942–7950. - PubMed
    1. Nguyen K, Devidas M, Cheng S-C, et al. Factors influencing survival after relapse from acute lymphoblastic leukemia: a Children’s Oncology Group study. Leukemia 2008;22(12):2142–2150. - PMC - PubMed
    1. Hunger SP, Mullighan CG. Redefining ALL classification: toward detecting high-risk ALL and implementing precision medicine. Blood 2015;125(26):3977–3987. - PMC - PubMed
    1. Mullighan CG, Phillips LA, Su X, et al. Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia. Science 2008;322(5906):1377–1380. - PMC - PubMed

LinkOut - more resources