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Comment
. 2015 Dec;30(12):709-711.
doi: 10.1016/j.tree.2015.10.003. Epub 2015 Oct 29.

An Individual-Centered Framework For Unravelling Genotype-Phenotype Interactions

Michel Baguette  1 , Delphine Legrand  2 , Virginie M Stevens  3
Affiliations
Comment

An Individual-Centered Framework For Unravelling Genotype-Phenotype Interactions

Michel Baguette et al. Trends Ecol Evol. 2015 Dec.

Abstract

A new framework in which the multiple levels of molecular variations contribute to phenotypic variations in a complex, nonlinear and interactive way, challenges the hierarchical nature of the relationships between the genotypic and phenotypic spaces. This individual-centered framework provides new insights on the evolutionary mechanisms involved in the production of phenotypes. We propose to move this research agenda forward by combining selection experiments and functional genetics.

Keywords: Genome; epigenome; molecular pedigree of evolutionary changes; phenome; proteome; syndrome.

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