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. 2015 Dec 1;25(23):5551-4.
doi: 10.1016/j.bmcl.2015.10.058. Epub 2015 Oct 21.

Structure-activity relationship of indoloquinoline analogs anti-MRSA

Min Zhao  1 , Tomonori Kamada  1 , Aya Takeuchi  1 , Hiromi Nishioka  1 , Teruo Kuroda  1 , Yasuo Takeuchi  2
Affiliations

Structure-activity relationship of indoloquinoline analogs anti-MRSA

Min Zhao et al. Bioorg Med Chem Lett. .

Abstract

Indolo[3,2-b]quinoline analogs (3a-3s), 4-(acridin-9-ylamino) phenol hydrochloride (4), benzofuro[3,2-b]quinoline (3t), indeno[1,2-b]quinolines (3u and 3v) have been synthesized. Those compounds were found to exhibit anti-bacterial activity towards Methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure-activity relationship studies were conducted that indoloquinoline ring, benzofuroquinoline ring and 4-aminophenol group are essential structure for anti-MRSA activity.

Keywords: Anti-MRSA; Benzofuroquinoline; Indenoquinoline; Indoloquinoline; Structure–activity.

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