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Case Reports
. 2015 Jul 30:21:228.
doi: 10.11604/pamj.2015.21.228.7525. eCollection 2015.

Palmar-plantar erythrodysesthesia associated with capecitabine chemotherapy: a case report

Gabriel Kigen  1 , Naftali Busakhala  1 , Evangeline Njiru  2 , Fredrick Chite  2 , Patrick Loehrer  3
Affiliations
Case Reports

Palmar-plantar erythrodysesthesia associated with capecitabine chemotherapy: a case report

Gabriel Kigen et al. Pan Afr Med J. .

Abstract

We report a case of a 62 year-old patient who developed Palmar-plantar erythrodysesthesia upon receiving four cycles of capacitabine-based chemotherapy. She was on post surgical adjuvant treatment for invasive well differentiated adenocarcinoma of the colon. The clinical and therapeutic aspects of this chemotherapeutic adverse effect are discussed.

Keywords: Kenya; Palmar-plantar erythrodysesthesia; capecitabine.

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Figures

Figure 1
Figure 1
Blisters on the palms of the patient's hand
Figure 2
Figure 2
Blisters on the right foot
Figure 3
Figure 3
Blisters on the left foot
Figure 4
Figure 4
The patient's palms showing the healed blisters
Figure 5
Figure 5
The patient's feet showing the healed blisters
See this image and copyright information in PMC

References

    1. Saif MW. Capecitabine and hand-foot syndrome. Expert Opin Drug Saf. 2011;10(2):p159–69. - PubMed
    1. Palaniappan M, et al. Anticancer drug induced palmar plantar erythrodysesthesia. J Clin Diagn Res. 2014;8(10):pHc01–3. - PMC - PubMed
    1. Webster-Gandy JD, How C, Harrold K. Palmar-plantar erythrodysesthesia (PPE): a literature review with commentary on experience in a cancer centre. Eur J Oncol Nurs. 2007;11(3):p238–46. - PubMed
    1. Scheithauer W, Blum J. Coming to grips with hand-foot syndrome. Insights from clinical trials evaluating capecitabine. Oncology (Williston Park) 2004 Aug;18(9):1161–8. 1173. - PubMed
    1. Lin E, Morris JS, Ayers GD. Effect of celecoxib on capecitabine-induced hand-foot syndrome and antitumor activity. Oncology (Williston Park) 2002;16(12 Suppl No 14):p31–7. - PubMed

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