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Review
. 2015;2(4):297-302.
doi: 10.1007/s40472-015-0077-2. Epub 2015 Oct 6.

Simultaneous Liver-Kidney Transplantation

Vichin Puri  1 , James Eason  1
Affiliations
Review

Simultaneous Liver-Kidney Transplantation

Vichin Puri et al. Curr Transplant Rep. 2015.

Abstract

In 2014, simultaneous liver kidney transplants (SLK) accounted for 8.2 % of all liver transplants performed in the USA. Prior to introduction of the model of end stage liver disease (MELD) system, SLK accounted for 2.5 % in 2001 and only 1.7 % in 1990. Transplant centers have struggled to balance the moral and ethical aspects of SLK in the setting of organ scarcity with an algorithm that best qualifies patients for such treatment options. Few centers have even ventured into DCD territory for SLK. Advancement in immunosuppression protocols and treatment of HCV and HIV have impacted SLK over the years. Simulation modeling has allowed us to analyze the future impact of our decisions that are made today. All of these advancements have given, and will continue to give new perspectives to SLK. The purpose of this review article is to highlight these advances and bring to light the studies that have made this transplant option successful.

Keywords: Combined liver-kidney transplant; Kidney transplant; Liver transplant; MELD score; Multi-organ transplant; OPTN; Simultaneous liver-kidney transplant.

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Figures

Fig. 1
Fig. 1
Algorithm for acute and chronic kidney disease in patients with ESLD [, •]
See this image and copyright information in PMC

References

    1. Nair S, Verma S, Thuluvath PJ. Pretransplant renal function predicts survival in patients undergoing orthotopic liver transplantation. Hepatology. 2002;35(5):1179–1185. doi: 10.1053/jhep.2002.33160. - DOI - PubMed
    1. Ojo AO, Held PJ, Port FK, et al. Chronic renal failure after transplantation of a nonrenal organ. New Engl J Med. 2003;349(10):931–940. doi: 10.1056/NEJMoa021744. - DOI - PubMed
    1. Gonwa TA, McBride MA, Anderson K, Mai ML, Wadei H, Ahsan N. Continued influence of preoperative renal function on outcome of orthotopic liver transplant in the US: Where will MELD lead us? Am J Transplant. 2006;6:2651–2659. doi: 10.1111/j.1600-6143.2006.01526.x. - DOI - PubMed
    1. OPTN data 1990 – 2014 http://optn.transplant.hrsa.gov
    1. Eason JD, Gonwa TA, Davis CL, et al. Proceedings of consensus conference on simultaneous liver kidney transplantation (SLK) Am J Transplant. 2008;8:2243. doi: 10.1111/j.1600-6143.2008.02416.x. - DOI - PubMed

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