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Randomized Controlled Trial
. 2017 Feb;56(1):161-170.
doi: 10.1007/s00394-015-1066-z. Epub 2015 Nov 2.

Association between body weight and composition and plasma 25-hydroxyvitamin D level in the Diabetes Prevention Program

Lisa Ceglia  1   2 , Jason Nelson  3 , James Ware  4 , Konstantinos-Dionysios Alysandratos  5 , George A Bray  6 , Cheryl Garganta  7 , David M Nathan  8 , Frank B Hu  9   10 , Bess Dawson-Hughes  11   12 , Anastassios G Pittas  11 ; Diabetes Prevention Program Research Group
Affiliations
Randomized Controlled Trial

Association between body weight and composition and plasma 25-hydroxyvitamin D level in the Diabetes Prevention Program

Lisa Ceglia et al. Eur J Nutr. 2017 Feb.

Abstract

Objective: We examined associations between body weight and plasma 25-hydroxyvitamin D concentration (25OHD) in prediabetes and sought to estimate the impact of adiposity on these associations.

Methods: The study was conducted in the placebo (n = 1082) and intensive lifestyle (n = 1079) groups of the Diabetes Prevention Program (DPP), a multicenter trial to prevent type 2 diabetes in adults with prediabetes. Weight and 25OHD were measured at baseline, month 6, years 1 and 2. In a subset (n = 584), visceral (VAT) and subcutaneous (SAT) adiposity were assessed by computed tomography at baseline and year 1.

Results: In cross-sectional analyses, baseline body weight, total fat, VAT, and SAT were inversely associated with plasma 25OHD concentration after multivariable adjustment. VAT accounted for 40 % [95 % CI 11, 69] of the association of body weight with plasma 25OHD concentration. There was no significant contribution by total fat or SAT. Two-year changes in plasma 25OHD concentration varied inversely with changes in body weight (p < 0.0001). One-year changes in total fat, VAT, or SAT were not significant mediators of the association between change in plasma 25OHD concentration and body weight.

Conclusion: Our study found an inverse association between body weight and plasma 25OHD concentration at baseline and over a 2-year period in adults with prediabetes. These findings in the DPP, a weight loss intervention study, raise the possibility that weight loss increases plasma 25OHD concentration. Whether adiposity mediates this association remains inconclusive.

Keywords: Adipose tissue; Body composition; Body weight; Diabetes Prevention Program; Obesity; Vitamin D.

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Figures

Figure 1
Figure 1
CONSORT Flow Diagram
Figure 2
Figure 2
Mean weight and 25OHD by treatment group during follow-up
See this image and copyright information in PMC

References

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