Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Sep;19(3):173-82.
doi: 10.5717/jenb.2015.15070703. Epub 2015 Jul 31.

The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats

Parvin Babaei  1 , Arsalan Damirchi  2 , Rastegar Hoseini  2
Affiliations

The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats

Parvin Babaei et al. J Exerc Nutrition Biochem. 2015 Sep.

Abstract

Purpose: The purpose of this study was to determine the interaction effects of aerobic exercise training and vitamin D supplementation on indices of obesity and plasma lipid profiles in ovariectomized (OVX) rats.

Methods: Forty female Wistar rats were divided into 5 groups: aerobic training (3 days/week for 8 weeks; AT; n = 8), aerobic training and vitamin D supplementation (OVX + AT + Vit D; n = 8), vitamin D supplementation (OVX + Vit D; n = 8), ovariectomized control (OVX + C, n = 8) and SHAM (n = 8). After blood sampling, visceral fat was taken from the abdominal cavity and weighed immediately. Data was statistically analyzed by One-way ANOVA and Repeated measure ANOVA tests with a 0.05 significance level.

Results: Body weight, visceral fat, BMI and food intake decreased significantly in OVX + AT + Vit D (P < 0.001); whereas these variables increased significantly in OVX + C (P < 0.001) and SHAM (P < 0.023) groups. At the end of two-months of follow-up, we observed significant differences in TC, TG, HDL-C, LDL-C, glucose, insulin, and HOMA-IR in all groups.

Conclusion: It seems that aerobic training with vitamin D, due to the involvement of muscle mass and exposure to dynamic pressure on the bones and muscles, increased energy expenditure, stimulated insulin exudation and glucose homeostasis, decreased insulin resistance and improved the lipid profile in ovariectomized rats.

Keywords: Aerobic Training; Food Intake; Postmenopausal Women; Visceral Fat; Vitamin D; plasma lipid profiles and insulin resistance.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Comparison of mean ± SD body weight between groups. One-way ANOVA test followed by Tukey’s post-hoc test. *Significant differences between the control and other groups (P < 0.001). ¥ Significant differences between the OVX + AT + Vit D and other groups (P < 0.002). # Significant differences between the SHAM and other groups (P < 0.002), the level of significance was set at 5% (P < 0.05); OVX + AT + Vit D, aerobic training with vitamin D supplementation group; OVX + AT, aerobic training; OVX + Vit D, vitamin D supplementation group; OVX + C, control group; SHAM, sham-operated (SHAM).
Fig. 2
Fig. 2
Comparison of mean ± SD food intake between groups. One-way ANOVA test followed by Tukey’s post-hoc test. *Significant differences between the control and other groups (P < 0.001). # Significant differences between the OVX + AT + Vit D and other groups (P < 0.001), the level of significance was set at 5% (P < 0.05); OVX + AT + Vit D, aerobic training with vitamin D supplementation group; OVX + AT, aerobic training; OVX + Vit D, vitamin D supplementation group; OVX + C, control group; SHAM, sham-operated (SHAM).
See this image and copyright information in PMC

References

    1. Cooke PS, Naaz A. Role of estrogens in adipocyte development and function. Experimental biology and medicine. 2004;229:1127–35. - PubMed
    1. Wajchenberg BL. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocrine reviews. 2000;21:697–738. - PubMed
    1. Ainslie D, Morris M, Wittert G, Turnbull H, Proietto J, Thorburn A. Estrogen deficiency causes central leptin insensitivity and increased hypothalamic neuropeptide Y. International journal of obesity and related metabolic disorders: journal of the International Association for the Study of Obesity. 2001;25:1680–8. - PubMed
    1. Roth SM, Zmuda JM, Cauley JA, Shea PR, Ferrell RE. Vitamin D receptor genotype is associated with fat-free mass and sarcopenia in elderly men. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2004;59:10–5. - PubMed
    1. Gambacciani M, Ciaponi M, Cappagli B, Piaggesi L, De Simone L, Orlandi R, et al. Body weight, body fat distribution, and hormonal replacement therapy in early postmenopausal women. The Journal of Clinical Endocrinology & Metabolism. 1997;82:414–7. - PubMed

LinkOut - more resources