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. 2015 Dec 24;126(26):2896-9.
doi: 10.1182/blood-2015-09-671131. Epub 2015 Nov 2.

Outcome of children with hypodiploid ALL treated with risk-directed therapy based on MRD levels

Charles G Mullighan  1 , Sima Jeha  2 , Deqing Pei  3 , Debbie Payne-Turner  1 , Elaine Coustan-Smith  4 , Kathryn G Roberts  1 , Esmé Waanders  5 , John K Choi  1 , Xiaotu Ma  6 , Susana C Raimondi  1 , Yiping Fan  6 , Wenjian Yang  7 , Guangchun Song  1 , Jun J Yang  7 , Hiroto Inaba  2 , James R Downing  1 , Wing H Leung  8 , W Paul Bowman  9 , Mary V Relling  7 , William E Evans  7 , Jinghui Zhang  6 , Dario Campana  4 , Ching-Hon Pui  10
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Outcome of children with hypodiploid ALL treated with risk-directed therapy based on MRD levels

Charles G Mullighan et al. Blood. .
No abstract available

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Figures

Figure 1
Figure 1
Kaplan-Meier estimates of event-free survival for all 20 patients with hypodiploid ALL and according to the presence (n = 6) or absence (n = 14) of MRD.
See this image and copyright information in PMC

References

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    1. Pui CH, Carroll AJ, Raimondi SC, et al. Clinical presentation, karyotypic characterization, and treatment outcome of childhood acute lymphoblastic leukemia with a near-haploid or hypodiploid less than 45 line. Blood. 1990;75(5):1170–1177. - PubMed
    1. Heerema NA, Nachman JB, Sather HN, et al. Hypodiploidy with less than 45 chromosomes confers adverse risk in childhood acute lymphoblastic leukemia: a report from the children’s cancer group. Blood. 1999;94(12):4036–4045. - PubMed
    1. Raimondi SC, Zhou Y, Mathew S, et al. Reassessment of the prognostic significance of hypodiploidy in pediatric patients with acute lymphoblastic leukemia. Cancer. 2003;98(12):2715–2722. - PubMed
    1. Harrison CJ, Moorman AV, Broadfield ZJ, et al. Childhood and Adult Leukaemia Working Parties. Three distinct subgroups of hypodiploidy in acute lymphoblastic leukaemia. Br J Haematol. 2004;125(5):552–559. - PubMed

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