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Review
. 2015 Nov 1;21(21):4743-6.
doi: 10.1158/1078-0432.CCR-14-3127.

CCR 20th Anniversary Commentary: Gene-Expression Signature in Breast Cancer--Where Did It Start and Where Are We Now?

Isabelle Gingras  1 , Christine Desmedt  2 , Michail Ignatiadis  3 , Christos Sotiriou  4
Affiliations
Review

CCR 20th Anniversary Commentary: Gene-Expression Signature in Breast Cancer--Where Did It Start and Where Are We Now?

Isabelle Gingras et al. Clin Cancer Res. .

Abstract

Desmedt and colleagues published two articles, one in the June 1, 2007 issue, and the other in the August 15, 2008, issue of Clinical Cancer Research, that showed gene-expression signatures to be proliferation driven and time dependent, with their prognostic power decreasing with increasing follow-up years. Moreover, the articles showed that immune response is a crucial determinant of prognosis in the HER2-positive and estrogen receptor-negative/HER2-negative subtypes, providing a rationale to further explore the role of the antitumor immune response in these breast cancer subtypes.

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