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. 2015 Oct 20:8:3017-20.
doi: 10.2147/OTT.S87146. eCollection 2015.

EGFR gene-mutation status correlated with therapeutic decision making in lung adenocarcinoma

Yaoyao Ren  1 , Yibing Yao  1 , Qing Ma  1 , Diansheng Zhong  1
Affiliations

EGFR gene-mutation status correlated with therapeutic decision making in lung adenocarcinoma

Yaoyao Ren et al. Onco Targets Ther. .

Abstract

The purpose of this study was to investigate the correlation between EGFR-mutation status and treatment efficacy for advanced lung adenocarcinoma patients. A total of 47 patients receiving erlotinib as first-line therapy were divided into two groups: the EGFR gene mutation group included 19 patients with known EGFR-sensitive mutations, and the EGFR-mutation status-unknown group comprised 28 patients with unknown EGFR-mutation status. Both objective response rate and disease-control rate were significantly higher in the EGFR-mutation group compared with the EGFR-unknown group (42.1% vs 14.2%, P=0.032; 94.7% vs 57.1%, P=0.005). Age, sex, smoking history, stage of disease, and tissue-sample source were not significantly correlated with the distributions of mutation status. In conclusion, it is important for advanced lung adenocarcinoma patients to undergo gene analysis before being assigned a molecularly targeted drug as first-line treatment.

Keywords: EGFR; gene mutation; lung adenocarcinoma.

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