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Review
. 2015;88(1):9-14.
doi: 10.15386/cjmed-377. Epub 2015 Jan 28.

The Importance of Ubiquitin E3 Ligases, SCF and APC/C, in Human Cancers

Ovidiu Vasile Bochis  1 , Bogdan Fetica  2 , Catalin Vlad  3 , Patriciu Achimas-Cadariu  3 , Alexandru Irimie  3
Affiliations
Review

The Importance of Ubiquitin E3 Ligases, SCF and APC/C, in Human Cancers

Ovidiu Vasile Bochis et al. Clujul Med. 2015.

Abstract

A normal evolution of the cell-cycle phases consists of multiple consecutive events, which makes it a highly complex process. Its preservation is regulated by Cyclin-Cdks (cyclin-dependent kinases) interactions and protein degradation, which is often controlled by the ubiquitin-mediated proteolysis. The goal of this review is to emphasize the most important features of the regulation of the cell-cycle involved in cancerogenesis, by presenting the involvement of E3 ubiquitin ligases SCF (Skp1-Cul1-F-box protein) and APC/C (Anaphase-promoting complex/cyclosome) in human malignancies. Also, we discuss the importance of the ubiquitin proteasome pathway blockade in cancer treatment. We know that a better understanding of the regulatory biology of the cell cycle can lead to the development of new target therapies for cancer.

Keywords: SCF; cancer; cell cycle; ubiquitin.

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