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Review
. 2015;88(1):9-14.
doi: 10.15386/cjmed-377. Epub 2015 Jan 28.

The Importance of Ubiquitin E3 Ligases, SCF and APC/C, in Human Cancers

Ovidiu Vasile Bochis  1 , Bogdan Fetica  2 , Catalin Vlad  3 , Patriciu Achimas-Cadariu  3 , Alexandru Irimie  3
Affiliations
Review

The Importance of Ubiquitin E3 Ligases, SCF and APC/C, in Human Cancers

Ovidiu Vasile Bochis et al. Clujul Med. 2015.

Abstract

A normal evolution of the cell-cycle phases consists of multiple consecutive events, which makes it a highly complex process. Its preservation is regulated by Cyclin-Cdks (cyclin-dependent kinases) interactions and protein degradation, which is often controlled by the ubiquitin-mediated proteolysis. The goal of this review is to emphasize the most important features of the regulation of the cell-cycle involved in cancerogenesis, by presenting the involvement of E3 ubiquitin ligases SCF (Skp1-Cul1-F-box protein) and APC/C (Anaphase-promoting complex/cyclosome) in human malignancies. Also, we discuss the importance of the ubiquitin proteasome pathway blockade in cancer treatment. We know that a better understanding of the regulatory biology of the cell cycle can lead to the development of new target therapies for cancer.

Keywords: SCF; cancer; cell cycle; ubiquitin.

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References

    1. Kudo Y, Tsunematsu T, Takata T. Deregulation of Anaphase-promoting Complex/cyclosome-dependent Proteolysis in Cancer. Journal of Oral Biosciences. 2010;52(4):388–401.
    1. Nakayama KI, Nakayama K. Ubiquitin ligases: cell-cycle control and cancer. Nat Rev Cancer. 2006;6(5):369–381. - PubMed
    1. Morgan DO. Principles of CDK regulation. Nature. 1995;374(6518):131–134. - PubMed
    1. Kotoshiba S, Gopinathan L, Pfeiffenberger E, Rahim A, Vardy LA, Nakayama K, et al. p27 is regulated independently of Skp2 in the absence of Cdk2. Biochim Biophys Acta. 2014;1843(2):436–445. - PMC - PubMed
    1. Sherr CJ. Mammalian G1 cyclins. Cell. 1993;73(6):1059–1065. - PubMed

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