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Review
. 2015 Oct 12:6:513.
doi: 10.3389/fimmu.2015.00513. eCollection 2015.

Immune Response Modulation by Vitamin D: Role in Systemic Lupus Erythematosus

Mirentxu Iruretagoyena  1 , Daniela Hirigoyen  1 , Rodrigo Naves  2 , Paula Isabel Burgos  1
Affiliations
Review

Immune Response Modulation by Vitamin D: Role in Systemic Lupus Erythematosus

Mirentxu Iruretagoyena et al. Front Immunol. .

Abstract

Vitamin D plays key roles as a natural immune modulator and has been implicated in the pathophysiology of autoimmune diseases, including systemic lupus erythematosus (SLE). This review presents a summary and analysis of the recent literature regarding immunoregulatory effects of vitamin D as well as its importance in SLE development, clinical severity, and possible effects of supplementation in disease treatment.

Keywords: systemic lupus erythematosus; vitamin D.

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Figures

Figure 1
Figure 1
Vitamin D effects on the innate and adaptive immune response. Vitamin D has been shown to enhance chemotaxis, antimicrobial peptides, and macrophage differentiation. It can also inhibit DCs maturation, Th1 and Th17 differentiation, and promotes immunoregulatory functions of Treg cells.
See this image and copyright information in PMC

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