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. 2015 Oct 12;11(5):1028-32.
doi: 10.5114/aoms.2015.54858.

The importance of vitamin D in the pathology of bone metabolism in inflammatory bowel diseases

Iwona Krela-Kaźmierczak  1 , Aleksandra Szymczak  1 , Liliana Łykowska-Szuber  1 , Piotr Eder  1 , Kamila Stawczyk-Eder  1 , Katarzyna Klimczak  1 , Krzysztof Linke  1 , Wanda Horst-Sikorska  2
Affiliations

The importance of vitamin D in the pathology of bone metabolism in inflammatory bowel diseases

Iwona Krela-Kaźmierczak et al. Arch Med Sci. .

Abstract

Etiological factors of bone metabolism disorders in inflammatory bowel diseases have been the subject of interest of many researchers. One of the questions often raised is vitamin D deficiency. Calcitriol acts on cells, tissues and organs through a vitamin D receptor. The result of this action is the multi-directional effect of vitamin D. The reasons for vitamin D deficiency are: decreased exposure to sunlight, inadequate diet, inflammatory lesions of the intestinal mucosa and post-gastrointestinal resection states. This leads not only to osteomalacia but also to osteoporosis. Of significance may be the effect of vitamin D on the course of the disease itself, through modulation of the inflammatory mechanisms. It is also necessary to pay attention to the role of vitamin D in skeletal pathology in patients with inflammatory bowel diseases and thus take measures aimed at preventing and treating these disorders through the supplementation of vitamin D.

Keywords: Crohn's disease; osteopenia; osteoporosis; ulcerative colitis; vitamin D.

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