Body mass index influence interferon-beta treatment response in multiple sclerosis

Silje Stokke Kvistad¹, Kjell-Morten Myhr², Trygve Holmøy³, Jūratė Šaltytė Benth⁴, Stig Wergeland⁵, Antonie G Beiske⁶, Kristian S Bjerve⁷, Harald Hovdal⁸, Finn Lilleås⁹, Rune Midgard¹⁰, Tom Pedersen¹¹, Søren J Bakke¹², Annika E Michelsen¹³, Pål Aukrust¹⁴, Thor Ueland¹⁵, Jørn V Sagen¹⁶, Øivind Torkildsen²

Affiliations

¹ Hormone Laboratory, Department of Laboratory Medicine and Pathology, Haukeland University Hospital, Bergen, Norway; Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway. Electronic address: sgns@helse-bergen.no.
² Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway; Norwegian Multiple Sclerosis Registry and Biobank, Department of Neurology, Haukeland University Hospital, Bergen, Norway; KG Jebsen MS Research Centre, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
³ Department of Neurology, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
⁴ Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Helse Sør-Øst Health Services Research Centre, Akershus University Hospital, Lørenskog, Norway.
⁵ Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway; Norwegian Multiple Sclerosis Registry and Biobank, Department of Neurology, Haukeland University Hospital, Bergen, Norway.
⁶ Multiple Sclerosis Centre Hakadal, Hakadal, Norway.
⁷ Department of Medical Biochemistry, St. Olav's Hospital, Trondheim University Hospital, Norway; Clinic of Laboratory Medicine, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway; Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway.
⁸ Department of Neurology, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.
⁹ Curato Oslo, Oslo, Norway.
¹⁰ Department of Neurology, Molde Hospital, Norway; Unit for Applied Clinical Research, Norwegian University of Science and Technology, Trondheim, Norway.
¹¹ Unilabs Drammen, Drammen, Norway.
¹² Department of Neuroradiology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
¹³ Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
¹⁴ Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Section for Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway; KG Jebsen Inflammatory Research Center, University of Oslo, Oslo, Norway.
¹⁵ Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Neuroradiology, Oslo University Hospital Rikshospitalet, Oslo, Norway; K.G. Jebsen Thrombosis Research and Expertise Center, University of Tromsø, Tromsø, Norway.
¹⁶ Hormone Laboratory, Department of Laboratory Medicine and Pathology, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Bergen, Norway.

PMID: 26531700
DOI: 10.1016/j.jneuroim.2015.09.008

Randomized Controlled Trial

Body mass index influence interferon-beta treatment response in multiple sclerosis

Silje Stokke Kvistad et al. J Neuroimmunol. 2015.

. 2015 Nov 15:288:92-7.

doi: 10.1016/j.jneuroim.2015.09.008. Epub 2015 Sep 26.

Authors

Affiliations

¹ Hormone Laboratory, Department of Laboratory Medicine and Pathology, Haukeland University Hospital, Bergen, Norway; Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway. Electronic address: sgns@helse-bergen.no.
² Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway; Norwegian Multiple Sclerosis Registry and Biobank, Department of Neurology, Haukeland University Hospital, Bergen, Norway; KG Jebsen MS Research Centre, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
³ Department of Neurology, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
⁴ Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Helse Sør-Øst Health Services Research Centre, Akershus University Hospital, Lørenskog, Norway.
⁵ Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway; Norwegian Multiple Sclerosis Registry and Biobank, Department of Neurology, Haukeland University Hospital, Bergen, Norway.
⁶ Multiple Sclerosis Centre Hakadal, Hakadal, Norway.
⁷ Department of Medical Biochemistry, St. Olav's Hospital, Trondheim University Hospital, Norway; Clinic of Laboratory Medicine, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway; Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway.
⁸ Department of Neurology, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.
⁹ Curato Oslo, Oslo, Norway.
¹⁰ Department of Neurology, Molde Hospital, Norway; Unit for Applied Clinical Research, Norwegian University of Science and Technology, Trondheim, Norway.
¹¹ Unilabs Drammen, Drammen, Norway.
¹² Department of Neuroradiology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
¹³ Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
¹⁴ Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Section for Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway; KG Jebsen Inflammatory Research Center, University of Oslo, Oslo, Norway.
¹⁵ Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Neuroradiology, Oslo University Hospital Rikshospitalet, Oslo, Norway; K.G. Jebsen Thrombosis Research and Expertise Center, University of Tromsø, Tromsø, Norway.
¹⁶ Hormone Laboratory, Department of Laboratory Medicine and Pathology, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Bergen, Norway.

PMID: 26531700
DOI: 10.1016/j.jneuroim.2015.09.008

Abstract

Obesity is a possible risk factor of multiple sclerosis (MS), but the association between obesity and MS disease activity has not been explored. In a cohort of 86 MS patients, 80% of overweight or obese patients (BMI≥25kg/m(2)) had MRI activity compared to 48% of the normal-weight patients (BMI<25kg/m(2)) (p=0.001) during interferon-beta treatment. NEDA-status (no evidence of disease activity) was defined as a composite that consisted of absence of any relapses, sustained disability-progression and MRI-activity. Among normal-weight patients 26% obtained NEDA-status compared to only 13% of patients with BMI >25 (p=0.05). This may indicate that BMI affects interferon-beta treatment response.

Keywords: Body mass index (BMI); Interferon-beta treatment; MRI disease activity; Multiple sclerosis; No evidence of disease activity; Treatment response.

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Body mass index influence interferon-beta treatment response in multiple sclerosis

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Body mass index influence interferon-beta treatment response in multiple sclerosis

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Medical