Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Jan;33(1):53-7.
doi: 10.1128/AAC.33.1.53.

Synergistic inhibition of human immunodeficiency virus type 1 and type 2 replication in vitro by castanospermine and 3'-azido-3'-deoxythymidine

V A Johnson  1 , B D Walker, M A Barlow, T J Paradis, T C Chou, M S Hirsch
Affiliations

Synergistic inhibition of human immunodeficiency virus type 1 and type 2 replication in vitro by castanospermine and 3'-azido-3'-deoxythymidine

V A Johnson et al. Antimicrob Agents Chemother. 1989 Jan.

Abstract

Castanospermine and 3'-azido-3'-deoxythymidine (zidovudine) were evaluated in combination against human immunodeficiency virus (HIV) replication in vitro. Castanospermine and 3'-azido-3'-deoxythymidine inhibited HIV type 1 synergistically in acutely infected H9 cells. In addition, they synergistically inhibited both HIV type 1 and HIV type 2 in peripheral blood mononuclear cells. There were no additional toxic effects of these agents in combination. Drug interactions were evaluated by the median-effect principle and the isobologram technique. Combinations of a glycosylation inhibitor, such as castanospermine, with 3'-azido-3'-deoxythymidine deserve consideration for HIV-related chemotherapeutic intervention.

PubMed Disclaimer

References

    1. Biochemistry. 1983 Aug 2;22(16):3975-84 - PubMed
    1. J Infect Dis. 1988 Aug;158(2):378-85 - PubMed
    1. Arch Biochem Biophys. 1984 May 1;230(2):668-75 - PubMed
    1. Adv Enzyme Regul. 1984;22:27-55 - PubMed
    1. Science. 1984 Oct 26;226(4673):451-3 - PubMed

Publication types

LinkOut - more resources