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Review
. 2015 Oct 30;11(5):240-3.
doi: 10.12965/jer.150235. eCollection 2015 Oct.

Interaction between HSP 70 and iNOS in skeletal muscle injury and repair

Kijeong Kim  1
Affiliations
Review

Interaction between HSP 70 and iNOS in skeletal muscle injury and repair

Kijeong Kim. J Exerc Rehabil. .

Abstract

Muscle injuries are frequently occurred in various sports. The biological process and mechanism of muscle repair after injury are well known through the many studies. This study aimed at presenting heat shock protein and nitric oxide synthase are to respond to muscle damage and repair. This section discusses the results obtained through many articles. Heat shock proteins (HSPs) are considered to play an essential role in protecting cells from damage, preparing them to survive on new environmental challenges. In addition, exercise-induced changes such as heat shock, oxidative, metabolic, muscular, and cytokine stress seem to be responsible for the HSP response to exercise. Also, inducible nitric oxide synthase (iNOS) generates nitric oxide (NO) for prolonged period and causes pathophysiological effects. Furthermore, iNOS is involved in processes such as cell injury, wound repair, embryogenesis, tissue differentiation, and suppression of tumorigenesis. In conclusion, the inhibition of HSP 70 on caspase-3 and apoptosis is associated with its inhibition on iNOS that leads to less NO production.

Keywords: Heat shock protein 70; Inducible nitric oxide; Muscle injury; Repair.

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