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. 2015 Nov 4:14:148.
doi: 10.1186/s12933-015-0310-4.

Visceral adiposity is associated with altered myocardial glucose uptake measured by (18)FDG-PET in 346 subjects with normal glucose tolerance, prediabetes, and type 2 diabetes

Gyuri Kim  1   2 , Kwanhyeong Jo  3   4 , Kwang Joon Kim  5 , Yong-ho Lee  6 , Eugene Han  7 , Hye-jin Yoon  8 , Hye Jin Wang  9 , Eun Seok Kang  10   11 , Mijin Yun  12
Affiliations

Visceral adiposity is associated with altered myocardial glucose uptake measured by (18)FDG-PET in 346 subjects with normal glucose tolerance, prediabetes, and type 2 diabetes

Gyuri Kim et al. Cardiovasc Diabetol. .

Abstract

Background: The heart requires constant sources of energy mostly from free fatty acids (FFA) and glucose. The alteration in myocardial substrate metabolism occurs in the heart of diabetic patients, but its specific association with other metabolic variables remains unclear. We aimed to evaluate glucose uptake in hearts of subjects with normal glucose tolerance (NGT), prediabetes, and type 2 diabetes mellitus (T2DM) using [(18)F]-fluorodeoxyglucose-positron emission tomography ((18)FDG-PET) in association with visceral and subcutaneous adiposity, and metabolic laboratory parameters.

Methods: A total of 346 individuals (NGT, n = 76; prediabetes, n = 208; T2DM, n = 62) in a health promotion center of a tertiary hospital were enrolled. The fasting myocardial glucose uptake, and visceral and subcutaneous fat areas were evaluated using (18)FDG-PET and abdominal computed tomography, respectively.

Results: Myocardial glucose uptake was significantly decreased in subjects with T2DM compared to the NGT or prediabetes groups (p for trend = 0.001). Multivariate linear regression analyses revealed that visceral fat area (β = -0.22, p = 0.018), fasting FFA (β = -0.39, p < 0.001), and uric acid levels (β = -0.21, p = 0.007) were independent determinants of myocardial glucose uptake. Multiple logistic analyses demonstrated that decreased myocardial glucose uptake (OR 2.32; 95% CI 1.02-5.29, p = 0.045) and visceral fat area (OR 1.02, 95% CI 1.01-1.03, p = 0.018) were associated with T2DM.

Conclusions: Our findings indicate visceral adiposity is strongly associated with the alteration of myocardial glucose uptake evaluated by (18)FDG-PET, and its association further relates to T2DM.

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Figures

Fig. 1
Fig. 1
Altered myocardial glucose uptake of [18F]-fluorodeoxyglucose (18FDG) in subjects according to the glycemic status. Each subject has a median value within the highest tertile of myocardial glucose uptake for normal glucose tolerance (NGT), prediabetes, and type 2 diabetes mellitus (T2DM)
Fig. 2
Fig. 2
Box plot of myocardial glucose uptake according to glycemic status. The box represents the upper and lower quartiles. Each + and horizontal line in the box indicates the mean and median value of myocardial glucose uptake, respectively. The bar denotes 10–90 percentiles. NGT normal glucose tolerance, T2DM type 2 diabetes mellitus
See this image and copyright information in PMC

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