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. 1989 Feb 7;160(3):405-7.
doi: 10.1016/0014-2999(89)90097-6.

Pancreastatin inhibits insulin release from Rin m 5F cells: reversion by pertussis toxin

A M Lorinet  1 , K Tatemoto, M Laburthe, B Amiranoff
Affiliations

Pancreastatin inhibits insulin release from Rin m 5F cells: reversion by pertussis toxin

A M Lorinet et al. Eur J Pharmacol. .

Abstract

Pancreastatin inhibited carbachol- but not forskolin- or GIP-stimulated insulin release from Rin m 5F cells. The inhibition induced by pancreastatin was dose-dependent, with an ED50 value of 4 nM, and reached a maximum (50% of inhibition) at 10(-7) M peptide. Pretreatment of cells with pertussis toxin abolished the inhibitory effect of pancreastatin on carbachol-induced insulin release. We suggest that pancreastatin exerts a direct inhibitory control on insulin release through a pertussis toxin-sensitive cAMP-independent pathway.

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