Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2015 Oct;28(4):225-8.
doi: 10.1293/tox.JTP-2015-0021. Epub 2015 Jul 3.

Vitelline cyst in the rat ileum

Takafumi Oshikata  1 , Azusa Kobayashi  1 , Shino Kumabe  1 , Kazufumi Kawasako  1 , Koshirou Katoku  1 , Mikio Mitsuishi  1 , Takeshi Kanno  1 , Masao Hamamura  1
Affiliations
Case Reports

Vitelline cyst in the rat ileum

Takafumi Oshikata et al. J Toxicol Pathol. 2015 Oct.

Erratum in

  • Errata (Printer's correction).
    [No authors listed] [No authors listed] J Toxicol Pathol. 2016 Jan;29(1):74. Epub 2016 Feb 17. J Toxicol Pathol. 2016. PMID: 26989306 Free PMC article.

Abstract

Congenital vitelline duct anomalies other than Meckel's diverticulum are rare in animals. A cyst of approximately 8 mm in diameter was observed on the antimesenteric surface of the ileal serosa in a 10-week-old female Crl:CD(SD) rat. Microscopically, the cyst closely resembled the ileum, but it did not communicate with the ileal lumen. We diagnosed this case as a vitelline cyst derived from the vitelline duct based on the location where it developed and its histological behavior. In rats, only Meckel's diverticulum has been reported with a congenital anomaly of the vitelline duct, and no other spontaneous anomalies including a vitelline cyst have been reported. This case may be the first report concerning a vitelline cyst in the rat ileum.

Keywords: Meckel’s diverticulum; ileum; rat; vitelline cyst; vitelline duct.

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
Schematic representation of various vitelline duct abnormalities, ,,. A, Meckel’s diverticulum; B, vitelline cyst; C, persistent fibrous cord; D, umbilical sinus; E, umbilical fistula; Umb, umbilicus; M, mesentery.
Fig. 2.
Fig. 2.
Gross appearance. Vitelline cyst located on the antimesenteric aspect of the ileum. A white macule was observed on the cyst (arrow). The vitelline cyst was cut along the vertical section of the junction with the ileum and the cyst (square).
Fig. 3.
Fig. 3.
Histopathological appearance. The left side is the ileum, and the right side is the vitelline cyst (A–F). SMA stain revealed the lamina muscularis mucosae (arrows) in the mucosa of the ileum and the vitelline cyst (B). Goblet cells in the mucosa of the ileum and the vitelline cyst show similar stainability for PAS (C) and AB (D) stains. The crypts contain Paneth cells (arrows) that have eosinophilic granules in the cytoplasm (E). The vitelline cyst does not communicate with the ileal lumen (F). Bar = 1 mm (A), 50 μm (B), 100 μm (C, D), 20 μm (E), 200 μm (F).
Fig. 4.
Fig. 4.
Histopathological appearance of the white macula on the cyst. Granulation tissue with mineralization and mucus exudate in the muscle layer and serosa are observed (HE). Bar = 100 μm.
Fig. 5.
Fig. 5.
Histopathological appearance of the white macula on the cyst. Thinning and necrosis/exfoliation of the mucosal epithelia are observed (HE). Bar = 20 μm.
See this image and copyright information in PMC

References

    1. Bauer SB, and Retik AB. Urachal anomalies and related umbilical disorders. Urol Clin North Am. 5: 195–211. 1978. - PubMed
    1. Dencker L. Trypan blue accumulation in the embryonic gut of rats and mice during the teratogenic phase. Teratology. 15: 179–184. 1977. - PubMed
    1. Iwashita A. Intestine-Nonneoplastic disease. In: Surgical Pathology, 4th ed. Mukai K, Manabe T, and Fukayama M (eds). Bunkodo, Tokyo. 503–559. 2006. (in Japanese).
    1. DiSantis DJ, Siegel MJ, and Katz ME. Simplified approach to umbilical remnant abnormalities. Radiographics. 11: 59–66. 1991. - PubMed
    1. Levy AD, and Hobbs CM. From the archives of the AFIP. Meckel diverticulum: radiologic features with pathologic Correlation. Radiographics. 24: 565–587. 2004. - PubMed

Publication types

LinkOut - more resources