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. 2015 Jul-Sep;8(3):151-8.
doi: 10.4103/0974-1208.165144.

Effect of endometrial biopsy on intrauterine insemination outcome in controlled ovarian stimulation cycle

Leena Wadhwa  1 , Amrita Pritam  1 , Taru Gupta  1 , Sangeeta Gupta  1 , Sarika Arora  2 , Rajkumar Chandoke  3
Affiliations

Effect of endometrial biopsy on intrauterine insemination outcome in controlled ovarian stimulation cycle

Leena Wadhwa et al. J Hum Reprod Sci. 2015 Jul-Sep.

Abstract

Objective: The objective was to evaluate the effect of endometrial biopsy (EB) on intrauterine insemination (IUI) outcome in controlled ovarian stimulation (COS) cycle.

Design: Prospective randomized control study.

Setting: Tertiary care center.

Materials and methods: A total of 251 subjects were enrolled in the study. Subjects undergoing COS with IUI were randomly allocated into three groups. Group A: EB was taken between D19 and 24 of the spontaneous menstrual cycles that precedes the fertility treatment and IUI, which was done in next cycle (n = 86). Group B: EB was taken before D6 of the menstrual cycle, and fertility treatment and IUI was done in the same cycle (n = 90). Group C: (control group) no EB in previous 3 cycle (n = 75).

Main outcome measure: Clinical pregnancy rate (CPR).

Results: Clinical pregnancy rate was 19.77%, 31.11%, and 9.3% for Group A, Group B, and Group C, respectively. The results show a highly significant value for the paired t-test of intervention Group B and control Group C of the cases (P = 0.000957). CPR was maximum after first cycle of ovulation induction and IUI following EB scratch in both Groups A and in Group B (P < 0.001).

Conclusions: Endometrial biopsy done in early follicular phase in the same cycle of stimulation with IUI gives better CPR as compared with EB done in the luteal phase of the previous cycle.

Keywords: Assisted reproductive technology; controlled ovarian stimulation; endometrial biopsy; intrauterine insemination.

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Consort flow Diagram
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References

    1. Norwitz ER, Schust DJ, Fisher SJ. Implantation and the survival of early pregnancy. N Engl J Med. 2001;345:1400–8. - PubMed
    1. Simón C, Martín JC, Pellicer A. Paracrine regulators of implantation. Baillieres Best Pract Res Clin Obstet Gynaecol. 2000;14:815–26. - PubMed
    1. de Mouzon J, Goossens V, Bhattacharya S, Castilla JA, Ferraretti AP, Korsak V, et al. Assisted reproductive technology in Europe, 2007: Results generated from European registers by ESHRE. Hum Reprod. 2012;27:954–66. - PMC - PubMed
    1. Barash A, Dekel N, Fieldust S, Segal I, Schechtman E, Granot I. Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization. Fertil Steril. 2003;79:1317–22. - PubMed
    1. Nastri CO, Gibreel A, Raine-Fenning N, Maheshwari A, Ferriani RA, Bhattacharya S, et al. Endometrial injury in women undergoing assisted reproductive techniques. Cochrane Database Syst Rev. 2012;7:CD009517. - PubMed

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