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. 2015 Dec 1;1(6):391-400.
doi: 10.1007/s40495-015-0036-8. Epub 2015 Apr 15.

Retinoid Chemoprevention: Who Can Benefit?

Rodica P Bunaciu  1 , Andrew Yen  1
Affiliations

Retinoid Chemoprevention: Who Can Benefit?

Rodica P Bunaciu et al. Curr Pharmacol Rep. .

Abstract

Acute promyelocytic leukemia (APL) is a treatment success story. From a highly deadly disease it was turned into a highly curable disease by the introduction of differentiation-induction therapy with all-trans retinoic acid (ATRA) in the 1990's. During the last quarter of century, ATRA and other retinoids were used for the treatment and prevention of other cancers and even other diseases. The results were less spectacular, but nevertheless important. Progress has been made toward understanding the mechanism of action of retinoids in different physiological and pathological contexts. For some diseases, specific genetic backgrounds were found to confer responsiveness to retinoid therapy. Therapies that include retinoids and other modalities are very diverse and used both for combined targeting of multiple pathways and for diminishing toxicity.

Keywords: chemoprevention; retinoic acid signaling; retinoid.

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Conflict of interest statement

Conflict of Interest: Rodica P. Bunaciu and Andrew Yen declare that they have no conflict of interest.

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