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Review
. 2015 Nov 5;11(11):e1005087.
doi: 10.1371/journal.ppat.1005087. eCollection 2015.

Emergence of Pathogenicity in Lagoviruses: Evolution from Pre-existing Nonpathogenic Strains or through a Species Jump?

Pedro José Esteves  1   2   3 , Joana Abrantes  1 , Stéphane Bertagnoli  4   5 , Patrizia Cavadini  6 , Dolores Gavier-Widén  7 , Jean-Sébastien Guitton  8 , Antonio Lavazza  9 , Evelyne Lemaitre  10   11 , Jérôme Letty  8 , Ana Margarida Lopes  1   2 , Aleksija S Neimanis  7 , Nathalie Ruvoën-Clouet  12 , Jacques Le Pendu  12 , Stéphane Marchandeau  8 , Ghislaine Le Gall-Reculé  10   11
Affiliations
Review

Emergence of Pathogenicity in Lagoviruses: Evolution from Pre-existing Nonpathogenic Strains or through a Species Jump?

Pedro José Esteves et al. PLoS Pathog. .
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Possible origin of European rabbit (O. cuniculus) lagoviruses according to the hypothesis of a species jump.
A) Lagoviruses that may share common ancestors following several species jump(s), B) Nonpathogenic viruses that have evolved in European rabbit for a long time. Phylogenetic tree (Neighbor-joining method) derived from 303 rabbit lagovirus sequences of the VP60 gene available on public databases (May 2015). The pathogenic RHDV, RHDVa, RHDV2, and the nonpathogenic RCV-A1 branches are collapsed; the name of the leporid species where these strains were isolated is given in brackets. X96868_RCV/1996-Italy, GQ166866_MRCV/2000-USA, EF558587_Ashington/1998-UK, and AM268419_06-11/2006-France are nonpathogenic strains isolated in the European rabbit. Percentage greater than 70% of replicate trees in which the associated taxa clustered together in the bootstrap test (500 replicates) are given at major branch nodes. The EBHSV strain GD (Z69620) was used as an outgroup to root the tree. Similar clustering was observed in several recent works [63,64,66,70,74].
See this image and copyright information in PMC

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